S.H.I.E.L.D.

Director of SHIELD Colonel Nick Fury	Head of SHIELD Maria Hill	Agent Phil Coulson	Agent Melinda May	Agent Sum

Agent Val Cooper	Vigilante Aiden Pearce	Agent Megan Haddad

S.W.O.R.D.

Director of SWORD Abigail Brand	Head of Science Beast	Agent Lockheed	Agent Death's Head	Captain Jack Harkness

International Operations

International Operations was an American intelligence agency that was founded by the Central Intelligence Agency in 1964 with the purpose of safeguarding the interests of the United States.
International Operations soon fell under the leadership of Director Miles Craven and became an independent organization focusing on researching superhumans.
International Operations first discovered the Gen-factor, one of the sources responsible for superhuman powers. Gen-factor was experimented on many test subjects in which it resulted in many either dead or turned insane, or in some cases heavily and physically mutated. Gen-factor was also exposed to Team-7 by Miles Craven on a fake mission, claiming later that it was a chemical weapon used by their enemy. Most of Team 7 started to develop superpowers, except for Michael Cray, whose powers wouldn't manifest until 20 years later. Other members went insane or committed suicide, but in the end only seven members of Team 7 had developed superpowers while retaining their humanity. These seven would sired children that inherited their fathers' powers and became known as Gen 13.

Director of I.O. Ivana Baiul	Sideways Bob	Verge	Edge	Edge

Thunderbolts

Director Karla Sofen	Dark Knight Michael Lane

S.H.A.D.E.

S.H.A.D.E. was created as a one-time elite espionage operation by President Lyndon Johnson. Over the decades, it survived in a minimalist form, as a low budget cleanup operation headquartered at the secret Essex Airbase.
The activities of S.H.A.D.E. are unknown until the present day, but what is known is that their budget was repeatedly slashed with the rise of superhumans. However, when all the heroes were occupied with the Infinite Crisis, S.H.A.D.E. became aware of the imminent attack of the Sheeda. When the Sheeda flagship appeared over New York City, they were reinstated as the American government's go-to agency for bizarre goings-on (particularly in light of the news that Checkmate, their predecessor organization, had gone rogue under the leadership of Maxwell Lord).