The enemies of the X-Men whose goals are separate from the causes of Mutants, Good or Evil. They oppose the X-Men either by virtue of seeking profit or power, or because of their hatred towards mutants.

Criminals

Arcade	Miss Locke	Miss Coriander	Mister Chambers	Juggernaut Cain Marko

Dog Logan	Nanny	Orphan Maker	Sauron Karl Lykos	Philistine

Lord Deathstrike	Ani-Mator

The Hand

The nascent Hand first formed about 800 years ago in feudal Japan, as a reaction to the oppressive class system that characterized Japanese society in that period. A number of Japanese citizens left their homes and settled in the mountains. There, they cultivated skill in ninjutsu, and through rigorous training became experts at assassination and espionage. The group officially came together in 1588 under the command of Kagenobu Yoshioka, who turned his samurai school into a bastion of support for the common man. Yoshioka was eventually assassinated, and command of the group co-opted by the Snakeroot, an ancient ninja clan who turned the Hand to demon worship and black magic. The Hand began working as mercenaries, and sought to extend its influence throughout the world.

Gorgon Tomi Shishido	Kaze Kouhai Hyuga	Anbu Irumi	Ensui Mifuyu Mikagami

Assassin's Guild

The Assassins Guild is a team of superhuman criminals in New Orleans founded by Candra. The Assassins Guild's main rival was the Thieves Guild.

To bring peace in the two bands, Marius Boudreaux agreed to marry his daughter Belladonna to the Thieves Guild's Gambit. Their wedding however was interrupted by Belladonna's brother Julien who felt Remy was unworthy of his sister's hand. Julien challenged Gambit to battle, but lost. Remy was banished as punishment for injuring a member of the Guild and abandoned Belladonna. The Guild itself however remained unified.

The Guilds seemingly separated and, years after her death, Candra returned, as her psyche managed to augment her remaining power and slowly pulled back the pieces of her body back together. The process was hastened by tributes from the Guild.[2]

The Guild eventually encountered Scarlet Spider when they were sent to kill his friend Dr. Donald Meland. Scarlet Spider was recognised by the Assassins as Kaine, with whom they had issues to settle with as he had previously killed on their territory.[3] Kaine was permitted to live as long as he promised to kill someone for Belladonna at a later date.[4]

Months later, the Belladonna sent Kaine to kill Wolverine.[5] Scarlet Spider managed to ally with Wolverine and they teamed-up in order to stop the Guild. When they arrived at New Orleans, it was revealed to them that Belladonna was following the orders of Candra,[6] who tried to get the essences of Scarlet Spider and Wolverine to finally return entirely. The two heroes managed to convince some Guild members to help them to stop Candra. She was finally killed when Scarlet Spider stung her head, although Belladonna claimed she would find a way to return. When Belladonna was about to order her men to kill Kaine and Wolverine, Kingpin's Arranger showed up and revealed to her the Assassins Guild's assets were now under his boss's control.

Candra	Marius Bourdeaux	Bella Donna Bourdeaux	Assassin Julien Bourdeaux	Clay

Flower	Gris-Gris	Harvester	Marcus Fifolet	Nahk

Questa	Shroud	Singer	Smithy

Children of the Vault

The Children of the Vault, a team of supervillians with Spanish-derived codenames. They have been revealed to be alive and appeared again recently. They are a genetic off-shoot of Homo Sapiens, and are considered a different species.