The rise in Manhattan's mutant population, coupled with racism among normal humans, led to mutants forming their own community in a ghetto established in the Alphabet City area of the East Village neighborhood of Manhattan. District X was the official title for the region; however, the region was more commonly referred to as Mutant Town. Mutant Town was very similar to, and served much the same purpose as, other minority ghettos in New York City like Chinatown, Harlem, Little Italy, or Greenwich Village. Soon the neighborhood was primarily populated by mutants, although some humans lived there as well. The neighborhood was poor, overcrowded, and violent, with a high rate of crime, narcotics use, prostitution, burglary, and warring mutant gangs. It was once described as having the "highest unemployment rate in the United States, the highest rate of illiteracy and the highest severe overcrowding outside of Los Angeles." Gang wars, such as the one between Daniel Kaufman and Frankie Zapruder, were frequent. Many of its inhabitants possessed physical mutations that prevented them from blending in with human society. It also had a large underground population, inhabiting tunnels beneath the neighborhood similar to those of the Morlocks years before, or the Tunnel Rats. Mutant Town was particularly notorious for the street drugs Kick, Toad, and MGH, sold by dealers such as Jazz and Charlie Hustle, or by Shaky Kaufman's and Filthy Frankie's gangs.

Center of Mutant Art & Culture

Despite the poverty and crime, Homo superior culture thrived here more than anywhere in the world outside of Genosha. Mutant Town quickly became a cultural center and population hub for a disenfranchised minority.
There was a range of mutant-owned businesses, clubs, and restaurants, including The Double Helix restaurant, X-Factory clothing, Café Des Artistes, Frankie's lounge, The Power Plant bar, and Mutatoo tattoo parlor. Mutant bands such as Sentinel Bait, Juggernaut and Cerebrastorm, along with nightclubs such as Daniel's Inferno, Wildkat Klub, Shakespeare's, and Wannabees created a vibrant, mutant-oriented nightlife. Many mutants used to work at such night-clubs, using their mutant powers or appearances, such as Lara King, Lorelei Travis, or Patricia Hamilton. Mutant artists began to emerge, such as Nemesio Pietri, while mutant fashion designers like Jumbo Carnation became celebrities and mutant clothing line like BuFu were founded. Mutant Town also gave rise to mutant spiritual leaders, such as Mr. M and Gregor Smerdyakov. X-Factor Investigations was founded to help fight crime, and X-Man Lucas Bishop was commissioned to police the area.

Locations of Note

Wildkat Klub: The Wildkat Klub was located in the district of New York City commonly referred to as Mutant Town. Residents were constantly exposed to the harassment of rival mutant gangs, bigoted humans, and capricious members of the NYPD.
Daniel's Inferno: Another mutant club.
McCarthy Avenue: One Batiment only, with many mutant residents.
11th Precinct Station House: The 11th Precinct Station House was the headquarters of the NYPD in Mutant Town, and had to deal with the social and criminality problems present in that area.
Power Plant: The Power Plant was a mutant-owned and operated bar located in Mutant Town and was directly across the street from the original X-Factor Investigations Headquarters. The Power Plant was a longtime bar in the heart of Mutant Town. Because it was located across the street from X-Factor Investigations Headquarters, the X-Factor Investigations crew frequentented the bar. After being recruited to XXX Investigations by Madrox, Wolfsbane met Strong Guy at the Power Plant for drinks. The fun was cut short when a dying dupe entered the bar and Jamie was forced to reabsorb him. To celebrate closing their first cases, the XXX Investigations crew went to have drinks at the Power Plant with their client Carol Campbell. Things got a bit dicey when Carol met Kim (her dead husband's male lover) and burst into flames. The Power Plant stayed open for after M-Day,[7] but business was never as good with many of the regulars moving away from the area. While Siryn was meeting a client in the Power Plant, the bar was gunned down and her client was murdered. After it was discovered that Multiple Man and/or one of his dupes slept with both Siryn and Monet on the same night, Jamie and Rictor had a heart to heart conversation over drinks at the Power Plant. While drinking alone (with a dupe), Madrox was approached by The Isolationist in the Power Plant. Following confession, Siryn told Monet about her unplanned pregnancy at the Power Plant.

Residents of Mutant Town

District X or Mutant Town was the setting of much mutant criminal activity as it was where the population was dominated by mutants, most of them with useless powers but nonetheless the majority of this area's citizens were criminals or involved in illegal activities. Former territory on the East Side of Manhattan that becomes an isolated city walled in by mutants after Old Hob sets off a mutagen bomb. The authorities, led by Baxter Stockman, decided that the city would be outside the jurisdiction of New York and that its citizens could not have any contact with the rest of the inhabitants of the city.

Armena Ortega	Chamayra Ortega	Esteban Ortega	Laline Ortega	Viktor

Andrea Hobbes	Walker Hobbes	Daniel Kauffman	Felon	Trickster Jae-Hwan Kim

Filthy Frank Frankie Zapruder	Hanna Levy	Jazz	Johnny Dee	Counselor Evangeline Whedon

Jumbo Carnation	Kiden Nixon	Lara King	Carrie	Zilug Zachariah Lugosh

Lefty	Lil' Bro	Lonnie Shakespeare	Lorelei Travis	Mister M

Mister Punch	Mrs. Berdereaux	Toad Boy Tarquin Berdereaux	Nathan Patrofsky	Amazing Mer-Woman Patricia Hamilton

The Comedian Paula	Siren	Sylvette Lauziere	Catiana Tatiana Cabian	Zippermouth

Billy Bates	Machine	Carol Campbell	Ned Campbell

Mutagen Bomb Mutants

When Old Hob detonated a Mutagen bomb at a party near Union Square Park, it caused a majority of the attendants, including several members of the Earth Protection Force, to become mutated into anthropomorphic animals. Upon Jonathan Bishop and Hun's assault on the crowd with the Slash clones, Hob had Sally Pride descend with the Mighty Mutanimals' aircraft, rounding up as many new mutants as would fit, before shuttling off. The map of Manhattan in the back of the issue indicates that the original mutagen bomb's fallout has expanded over a significant portion of the East Side and towards the East River, including the the neighborhoods surrounding the church where the Turtles live, teasing that there may be more mutations to come.
By six months after the mutation incident, these mutagen-contaminated neighborhoods had been designated a quarantine zone which became known as Mutant Town. All remaining unmutated humans had been evacuated out of the zone and into separate decontamination quarantines, and all of the newly mutated humans—estimated to number between several hundred and three thousand—had been forcibly confined inside the zone. Mayor Stockman had had a 50-foot wall built around the entire zone, and the city had established a strict indefinite enforced by the Earth Protection Force, officially to last until the area could be decontaminated of mutagenic agents and the mutated humans' mutations somehow reversed. Since it became clear this was not going to happen in the foreseeable future, Mutant Town became a ghetto for these mutated humans, and their life within its walls had to deal with denied opportunities, separation or dispossession from family and loved ones, dilapidated neighborhoods, abject poverty, homelessness, hunger, cold, and in many cases a difficulty adjusting to their physical changes. It was only after the Darkseid War that the Mutants were reintegrated with the rest of New York.

King Komodo	Diamond	Flyborg	Wenceslaus	Lindsay Baker

Amy	Anchovy	Athena	Bea	Chloe

Laurel	Felix	Fido Kimball	Herman	Seymour Gutz

Jay	Jo	Man-Ray	Moja	Wyrm

Mona Lisa	Mondo Gecko	Oceana	Odyn	Pigeon Pete

Puggle	Sally Pride	Screwloose	Scumbug	Sheena

Siobhan	Stewart	Terry	Wanda	Zodi

Krisa	Dreadmon	Quarry	Stonebiter	Leatherhead

Branden	Manchester	Mohawk	The Ape-Man	Dr. Jasper Barlow

Ivan	Millicent	Night The Lemur	Olive	Ramon

Reno	Roxy	Scrag	Silas	Stone

Tamra The Terror	The Slithery	Winny	Veronica	Vincent

Guardians

Those who protect Mutant Town outside the purview of the New York Police Department.

X-Factor Investigations

X-Factor Investigations was founded as a detective agency run by Jamie Madrox, a.k.a. the Multiple Man, a mutant with self-replication abilities. Using his connections to FBI, Madrox became a licensed detective and established an office in District X, the neighborhood known as Mutant Town. The agency was initially named "XXX Investigations". In his work, he counted with help in the form of his former teammates from the defunct mutant government-sponsored team X-Factor, namely Rahne Sinclair, the lycanthropic Wolfsbane, and Guido Carosella, the Strong Guy. Madrox's duplicates had been acting erratically as of late, which became the central point in the mysteries he had to solve.
When investigating the murder of one of his duplicates in Chicago alongside the psychic Stringer, Madrox learned about a connection to Sheila DeSoto, the wife of the multi-millionaire criminal Edward Vance. When meeting DeSoto, only to realize his duplicate was in a romantic affair with her, another duplicate of his was targetted for assassination at his office by Vance's hitman Clay.[4] Guido and Wolfsbane tackled Clay, while Madrox was captured by Vance, eventually discovering a duplicate of his was working against him.[5] Madrox was able to reabsorb his rogue duplicate and run away with DeSoto, who informed him Vance was obsessed about a mysterious mutant trying to take control over his criminal empire in Chicago.[6] The mastermind was ironically revealed to be DeSoto herself, who was Clay's actual employer and murdered Stringer. Madrox tricked DeSoto into believing he had killed Vance. As she counter-attacked, Vance surprisingly executed her. Back home, Madrox found his office rebranded as X-Factor Investigations, since his partners claimed it used to sound too much like a pornographic outfit. From then on, X-Factor focused on investigating bizarre mysteries, especially those involving mutant-related issues.

Jamie Madrox	Guido Carosella	Rahne Sinclair	Julio Esteban Rictor	Layla Miller

Gaveedra Seven	Monet St. Croix	Pip The Troll	Teresa Cassidy

Hamato Clan

Hamato Yoshi (Splinter) and Oroku Saki (the Shredder) were perhaps the greatest practitioners of Ninjutsu in the clan. Saki was the son of the Foot Clan leader and as an infant, and he was adopted by the Hamato Clan after the Foot Clan was wiped out. Yoshi and Saki grew up together and viewed one another as brothers until the two began to compete for the love of Tang Shen, a beautiful young woman. Eventually, Saki found out that he once belonged to the Foot Clan and felt betrayed, rebuild his birth clan, and he faced Splinter in combat and burned down his family dojo; Shen was accidentally killed by Saki. Saki effectively extinguished the Hamato Clan by turning its remaining ninjas to his side. Splinter managed to leave his fight with Saki alive, however, and moved to New York City where he bought four baby turtles. These turtles mutated in a freak accident and gained human intelligence. Splinter began to teach the Turtles the secrets of the Hamato Clan, so it now lives on.
They have become the protectors of Mutant Town, bringing some street justice to the otherwise hard to police area of New York. The true members of the Clan are the Hamato Family, but others have taken up their desire to keep their city safe, and have begun to learn martial arts in order to protect their community, especially in the aftermath of the Darkseid War.

Master Splinter Splinter Hamato	Leonardo Hamato	Raphael Hamato	Donatello Hamato	Michelangelo Hamato

Artemisia	Doro	Jennika	Venus	Kirby

Lita	Uno	Yee	Jinx

Street Sharks

A university professor named Dr. Robert Bolton and his partner Dr. Luther Paradigm created a machine known as the "gene-slammer" which is capable of changing aquatic animals into anthropomorphic hybrids by combining their DNA. In his attempt to prevent Paradigm from using this machine for personal power, Bolton is transformed into an unseen monstrosity, but escapes. Later, Paradigm gives Bolton's four sons John, Bobby, Coop, and Clint the likeness of four different sharks. When Dr. Paradigm captures their friend Bends, the resulting "Street Sharks" rescue him and combine Paradigm with piranha DNA (for which he is often nicknamed "Dr. Piranoid" by other characters). In subsequent weeks, Dr. Paradigm creates a variety of monsters to destroy the Street Sharks while attempting to persuade the inhabitants of their native metropolis of Fission City to imprison them.

Big Slammu	Jab	Ripster	Streex

Cheetahmen

They were created when they were cubs by the evil geneticist Dr. Morbiss when he killed their mother and took them for genetic research and turned them into half human, half cheetah creatures. They learn of Dr. Morbiss's plans and turn on him and escape, ultimately becoming his greatest enemy. They are Karate Cheetahs.

Apollo	Aries	Hercules

Renegades

Criminals who live up to the image of so-called 'Evil Mutants'. However, the majority of these do not rise to the level of 'Supervillain', being mostly gang bangers and thieves, and not exactly out for self-aggrandizement or domination, simply out for survival, profit, and territory.

Punk Frogs

The Punk Frogs are a mixture of envy and innate violence. Frogs are natural hunters and predators, with a high level of aggression, and these happen to have the mental and physical age of rebellious adolescents. Though not combat-enhanced, they are still aggressive, and are what one could consider the 'bad guys' in Mutant Town. They are known to cause trouble, ranging from harassment to occasional fights breaking out, and they style themselves after aggressive punks and violent, rebellious youth. They are, however, aware there's only so much they can do before confronting the militia, and aware they can't leave the town. However, they are known to flee at night and go cause trouble in nearby towns. The town, for their part, is worried they'll bring law enforcement or anti-mutant activists to Mutant Town, and as such the group is at odds with the other citizens. They are also likely responsible for bringing illegal substances like bootleg alcohol and drugs in town, yet another reason why the population is worried.

Atilla	Genghis	Napoleon	Rasputin	Bloody Mary

Clyde	Zetian

Mighty Mutanimals

Old Hob was originally the pet cat of a young boy, until the boy's angry mother threw him out in the street to punish her son for not cleaning up after him. Hob lived a miserable life as a stray, until he came across the Turtles and Splinter after they were dropped by the pair of ninja that had stolen them from StockGen. The mutagen that was also stolen spilled, and Hob came into contact with it, causing him to mutate. He tried to scurry off with a pre-mutated Raphael, but Splinter attacked, clawing out one of Hob's eyes. Hob would later mutate and team up with Baxter Stockman to get revenge on Splinter and the Turtles. Since the mutagen Hob came into contact was contaminated, he was sent to bring in the other mutants dead or alive in order to get mutagen samples from their blood. He used hard cash supplied by Stockman to pay and organize a street gang and tried multiple times to take down Splinter and the Turtles. Hob had a gang of humans that worked for him, but later co-founded the Mutanimals along with Slash, which became called the Mighty Mutanimals as its membership grew. This did not last, especially with the presence of Morlocks and the aftermath of the Darkseid War, leaving many Mutanimals to join with the Foot Clan. Now they are mostly thieves and pickpockets who used to be children.